USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P19971 USC-OGP 2-DE database:  P19971 P19971 General information about the entry View entry in simple text format Entry name TYPH_HUMAN Primary accession number P19971 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Thymidine phosphorylase; Short=TP; EC=2.4.2.4; AltName: Full=Gliostatin; AltName: Full=Platelet-derived endothelial cell growth factor; Short=PD-ECGF; AltName: Full=TdRPase; Flags: Precursor;. Gene name Name=TYMP Synonyms=ECGF1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0358: pI=5.18; Mw=51715 Cross-references UniProtKB/Swiss-Prot P19971; TYPH_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name TYPH_HUMAN Primary accession number P19971 Secondary accession number(s) A8MW15 H9KVA0 Q13390 Q8WVB7 Sequence was last modified on  June 7, 2005 (version 2) Annotations were last modified on  March 15, 2017 (version 197) Name and origin of the protein Description RecName: Full=Thymidine phosphorylase; Short=TP; EC=2.4.2.4; AltName: Full=Gliostatin; AltName: Full=Platelet-derived endothelial cell growth factor; Short=PD-ECGF; AltName: Full=TdRPase; Flags: Precursor; Gene name Name=TYMP Synonyms=ECGF1 Encoded on Name=TYMP; Synonyms=ECGF1 Keywords 3D-structure; Alternative splicing; Angiogenesis; Chemotaxis; Complete proteome; Developmental protein; Differentiation; Direct protein sequencing; Disease mutation; Glycosyltransferase; Growth factor; Phosphoprotein; Polymorphism; Progressive external ophthalmoplegia; Reference proteome; Repeat; Transferase. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M63193; AAA60043.1; -; mRNA EMBL AK225269; -; NOT_ANNOTATED_CDS; mRNA EMBL U62317; AAB03344.2; -; Genomic_DNA EMBL BC018160; AAH18160.1; -; mRNA EMBL BC052211; AAH52211.1; -; mRNA CCDS CCDS14096.1; -. [P19971-1]; . CCDS CCDS58811.1; -. [P19971-2]; . PIR S03904; S03904; . RefSeq NP_001107227.1; NM_001113755.2. [P19971-1]; . RefSeq NP_001107228.1; NM_001113756.2. [P19971-1]; . RefSeq NP_001244917.1; NM_001257988.1. [P19971-1]; . RefSeq NP_001244918.1; NM_001257989.1. [P19971-2]; . RefSeq NP_001944.1; NM_001953.4. [P19971-1]; . UniGene Hs.180903; -; . UniGene Hs.730607; -; . PDB 1UOU; X-ray; 2.11 A; A=12-482 PDB 2J0F; X-ray; 2.31 A; A/B/C/D=1-482 PDB 2WK5; X-ray; 2.99 A; A/B/C/D=1-482 PDB 2WK6; X-ray; 2.50 A; A/B=1-482 PDBsum 1UOU; -; . PDBsum 2J0F; -; . PDBsum 2WK5; -; . PDBsum 2WK6; -; . ProteinModelPortal P19971; -; . SMR P19971; -; . BioGrid 108219; 21; . IntAct P19971; 2; . STRING 9606.ENSP00000252029; -; . BindingDB P19971; -; . ChEMBL CHEMBL3106; -; . DrugBank DB01101; Capecitabine; . DrugBank DB00369; Cidofovir; . DrugBank DB00322; Floxuridine; . DrugBank DB00544; Fluorouracil; . DrugBank DB00432; Trifluridine; . iPTMnet P19971; -; . PhosphoSitePlus P19971; -; . SwissPalm P19971; -; . BioMuta TYMP; -; . DMDM 67477361; -; . OGP P19971; -; . MaxQB P19971; -; . PaxDb P19971; -; . PeptideAtlas P19971; -; . PRIDE P19971; -; . DNASU 1890; -; . Ensembl ENST00000252029; ENSP00000252029; ENSG00000025708. [P19971-1]; . Ensembl ENST00000395678; ENSP00000379036; ENSG00000025708. [P19971-1]; . Ensembl ENST00000395680; ENSP00000379037; ENSG00000025708. [P19971-1]; . Ensembl ENST00000395681; ENSP00000379038; ENSG00000025708. [P19971-2]; . GeneID 1890; -; . KEGG hsa:1890; -; . UCSC uc003bmb.7; human. [P19971-1]; . CTD 1890; -; . DisGeNET 1890; -; . GeneCards TYMP; -; . GeneReviews TYMP; -; . HGNC HGNC:3148; TYMP; . HPA CAB002518; -; . HPA HPA000530; -; . HPA HPA001072; -; . MalaCards TYMP; -; . MIM 131222; gene; . MIM 603041; phenotype; . neXtProt NX_P19971; -; . OpenTargets ENSG00000025708; -; . Orphanet 298; Mitochondrial neurogastrointestinal encephalomyopathy; . PharmGKB PA162407502; -; . eggNOG ENOG410IIV8; Eukaryota; . eggNOG COG0213; LUCA; . GeneTree ENSGT00390000009250; -; . HOGENOM HOG000047313; -; . HOVERGEN HBG000082; -; . InParanoid P19971; -; . KO K00758; -; . OMA EVGCCIV; -; . OrthoDB EOG091G08UG; -; . PhylomeDB P19971; -; . TreeFam TF332198; -; . BioCyc MetaCyc:HS00442-MONOMER; -; . BRENDA 2.4.2.4; 2681; . Reactome R-HSA-73614; Pyrimidine salvage reactions; . Reactome R-HSA-73621; Pyrimidine catabolism; . SABIO-RK P19971; -; . UniPathway UPA00578; UER00638; . EvolutionaryTrace P19971; -; . GeneWiki ECGF1; -; . GenomeRNAi 1890; -; . PRO PR:P19971; -; . Proteomes UP000005640; Chromosome 22; . Bgee ENSG00000025708; -; . CleanEx HS_TYMP; -; . ExpressionAtlas P19971; baseline and differential; . Genevisible P19971; HS; . GO GO:0005829; C:cytosol; IBA:GO_Central; . GO GO:0004645; F:phosphorylase activity; IBA:GO_Central; . GO GO:0016154; F:pyrimidine-nucleoside phosphorylase activity; IEA:InterPro; . GO GO:0009032; F:thymidine phosphorylase activity; IEA:UniProtKB-EC; . GO GO:0016763; F:transferase activity; transferring pentosyl groups; EXP:Reactome GO GO:0001525; P:angiogenesis; IEA:UniProtKB-KW; . GO GO:0030154; P:cell differentiation; IEA:UniProtKB-KW; . GO GO:0006935; P:chemotaxis; IEA:UniProtKB-KW; . GO GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:InterPro; . GO GO:0046135; P:pyrimidine nucleoside catabolic process; TAS:Reactome; . GO GO:0043097; P:pyrimidine nucleoside salvage; TAS:Reactome; . Gene3D 3.40.1030.10; -; 1; . Gene3D 3.90.1170.30; -; 1; . InterPro IPR000312; Glycosyl_Trfase_fam3; . InterPro IPR017459; Glycosyl_Trfase_fam3_N_dom; . InterPro IPR013102; PYNP_C; . InterPro IPR018090; Pyrmidine_PPas_bac/euk; . InterPro IPR017872; Pyrmidine_PPase_CS; . InterPro IPR000053; Thymidine/pyrmidine_PPase; . PANTHER PTHR10515; PTHR10515; 1; . Pfam PF02885; Glycos_trans_3N; 1; . Pfam PF00591; Glycos_transf_3; 1; . Pfam PF07831; PYNP_C; 1; . PIRSF PIRSF000478; TP_PyNP; 1; . SMART SM00941; PYNP_C; 1; . SUPFAM SSF47648; SSF47648; 1; . SUPFAM SSF52418; SSF52418; 1; . SUPFAM SSF54680; SSF54680; 1; . TIGRFAMs TIGR02644; Y_phosphoryl; 1; . PROSITE PS00647; THYMID_PHOSPHORYLASE; 1; .

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